Strategic Use of Dermatopicals Containing Ophytrium in Veterinary…

Presented by Anthony Yu, BSc, DVM, MSc, Dipl. ACVD

Continuing education questionnaire

CE credit: 1

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Questions

1. Chlorhexidine digluconate kills bacteria primarily by inhibiting cell wall synthesis, the same general mechanism as β-lactam antibiotics. True or False. *

True

False

2. Per the NARMS/NAHLN surveillance data (2017–2024), approximately what percentage of canine Staphylococcal skin isolates submitted to U.S. diagnostic labs were methicillin/oxacillin-resistant? *

12.5%

24.0%

36.5%

58.0%

3. Which ingredient is described as a "pro-ceramide" that stimulates endogenous ceramide synthesis in keratinocytes? *

Ophytrium

Phytosphingosine

Chlorhexidine digluconate

Seboliance

4. Ophytrium, the key ingredient in the current Douxo® S3 line, is derived from which source? *

Aloe vera leaf extract

Ophiopogon japonicus (mondo grass) root extract

Marine algae fucoidan

Colloidal oatmeal

5. Per the 2025 ISCAID canine pyoderma guidelines, there are legitimate clinical reasons to choose systemic antibiotics over topical therapy alone for superficial bacterial folliculitis when an owner is able to apply topical treatment. True or False. *

True

False

6. Morais et al. (2025, Frontiers in Microbiology) identified which gene on a plasmid (pSP5912) in Staphylococcus pseudintermedius, conferring reduced susceptibility to biocides/quaternary ammonium compounds? *

mecA

qacG

tet(K)

blaZ

7. In Lin, Huang, and Ho's (2026) electroporation study, introducing qacA into Staphylococcus aureus strain RN4220 raised the chlorhexidine MIC by approximately how much? *

2-fold (1→2 μg/mL)

4-fold (1→4 μg/mL)

8-fold (1→8 μg/mL)

No significant change

8. McHale et al. (2026) found that combining Ophytrium with 3% chlorhexidine digluconate blunted the antiseptic's bactericidal performance compared to chlorhexidine alone. True or False. *

True

False

9. According to Binversie et al. (2026), what did the in vitro comparison of 12 chlorhexidinecontaining shampoos show? *

Lathering ability was strongly correlated with chlorhexidine concentration

Products with identical labelled chlorhexidine concentrations performed identically

Products with identical labelled chlorhexidine concentrations performed significantly differently — formulation matters beyond %CHX

Non-chlorhexidine formulations outperformed all chlorhexidine products

10. Under the stewardship-based shampoo protocol, once infection resolves and cytology is negative, chlorhexidine products should be replaced with non-antiseptic Ophytrium- or phytosphingosine-based maintenance products. True or False. *

True

False